| Description | PI3K-IN-6 is an oral active and highly selective inhibitor of phosphoinositide 3-kinase (PI3K) β/δ(IC50 values of 7.8 nM/5.3 nM , respectively). |
| Target activity | PI3Kα:850 nM, PI3Kβ:7.8 nM, PI3Kδ:5.3 nM |
| molecular weight | 450.26 |
| Molecular formula | C17H14Cl2FN9O |
| CAS | 1842380-77-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Perreault S, et al. Discovery of a Phosphoinositide 3-Kinase (PI3K) β/δ Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3Kβ Potency in a PI3Kδ-Selective Template by Targeting Nonconserved Asp856. J Med Chem. 2017 Feb 23;60(4):1555-1567. |