| Description | PI3K/HDAC-IN-1 is a potent PI3K and HDAC dual inhibitor(IC50s of 8.1 nM and 1.4 nM, respectively). |
| Target activity | HDAC6:6.6 nM, PI3Kγ:67 nM, HDAC8:18 nM, HDAC1:1.4 nM, PI3Kα:42 nM, PI3Kβ:101 nM, PI3Kδ:8.1 nM, HDAC2:3.0 nM |
| molecular weight | 428.46 |
| Molecular formula | C22H25FN4O4 |
| CAS | 2361418-52-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Zhang K, et al. Design, Synthesis, and Biological Evaluation of 4-Methyl Quinazoline Derivatives as Anticancer Agents Simultaneously Targeting Phosphoinositide 3-Kinases and Histone Deacetylases. J Med Chem. 2019 May 29. |