| Description | Phorbol 12,13-dibutyrate is a PKC activator. It also is a potent skin tumor promoter. |
| In vitro | Phorbol 12,13-dibutyrate (1 MM) activates PKC. It also inhibited Na/K-ATPase transport activity in OK cells[3]. |
| Synonyms | PDBu, Phorbol dibutyrate |
| molecular weight | 504.61 |
| Molecular formula | C28H40O8 |
| CAS | 37558-16-0 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 125 mg/mL (247.72 mM) |
| References | 1. Singh J, et al. Immunocytochemical evidence for PDBu-induced activation of RhoA/ROCK in human internal anal sphincter smooth muscle cells. Am J Physiol Gastrointest Liver Physiol. 2011 Aug;301(2):G317-25. 2. Szallasi Z, et al. Dissociation of phorbol esters leads to immediate redistribution to the cytosol of protein kinases C alpha and C delta in mouse keratinocytes. J Biol Chem. 1994 Nov 4;269(44):27159-62. 3. Middleton JP, et al. Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells. J Biol Chem. 1993 Jul 25;268(21):15958-64. |