| Description | Phenyl-β-D-glucopyranoside (PHENYL-B-D-GLUCOPYRANOSIDE) is a component of Phellodendron amurense with anti-cancer and anti-inflammatory activities. |
| In vitro | Phenyl-β-D-Glucopyranoside 在Lipopolysaccharide激活的RAW 264.7细胞中表现出抗炎活性。Phenyl-β-D-Glucopyranoside 不仅抑制了一氧化氮 (NO) 的产生，而且显著抑制了诱导性NO合酶 (iNOS) 和环氧化酶-2 (COX-2) 的表达，且未引起细胞毒性。此外，Phenyl-β-D-Glucopyranoside 以浓度依赖性的方式减轻了包括肿瘤坏死因子-α (TNF-α)、白细胞介素-1β (IL-1β) 在内的前炎性细胞因子及其他炎症相关基因如IL-6的活性。更进一步，Phenyl-β-D-Glucopyranoside消除了内毒素处理诱导的增加的细胞黏附、神经损伤素 1 (Ninj1) 表达和基质金属蛋白酶 (MMP) 活性。最终，Phenyl-β-D-Glucopyranoside 抑制了涉及炎症过程中最重要的转录因子之一核因子-κB (NF-κB) 的核内转移。 |
| Synonyms | 苯基-BETA-葡萄糖吡喃糖苷, PHENYL-B-D-GLUCOPYRANOSIDE |
| molecular weight | 256.25 |
| Molecular formula | C12H16O6 |
| CAS | 1464-44-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | H2O: soluble DMSO: 60 mg/ml (234.15 mM) |
| References | 1. Hwang SJ, Lee HJ. Phenyl-β-D-Glucopyranoside Exhibits Anti-inflammatory Activity in Lipopolysaccharide-Activated RAW 264.7 Cells. Inflammation. 2015;38(3):1071-9. |