| Description | Pfn1-IN-C1, an inhibitor of Profilin1 (Pfn1), has been shown to reduce the overall level of cellular filamentous (F)-actin, slow EC migration and proliferation, and inhibit the angiogenic ability of EC both in vitro and ex vivo. |
| Synonyms | Pfn1INC1, Pfn1 IN C1, Pfn1 inhibitor C1 |
| molecular weight | 373.37 |
| Molecular formula | C19H15N7O2 |
| CAS | 919010-46-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Gau D, Lewis T, Mcdermott L, Wipf P, Koes D, Roy P. Structure-based virtual screening identifies small molecule inhibitor of the profilin1-actin interaction. J Biol Chem. 2017 Dec 27. pii: jbc.M117.809137. doi: 10.1074/jbc.M117.809137. [Epub ahead of print] PubMed PMID: 29282288. |