PeptideDB

PF-739

CAS No.: 1852452-14-2

PF-739 is an AMPK agonist that has been shown to activate AMPK in hepatocytes and skeletal muscle.
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Description PF-739 is an AMPK agonist that has been shown to activate AMPK in hepatocytes and skeletal muscle.
molecular weight 442.89
Molecular formula C23H23ClN2O5
CAS 1852452-14-2
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
References 1. Weihrauch M, Handschin C. Pharmacological targeting of exercise adaptations in skeletal muscle: Benefits and pitfalls. Biochem Pharmacol. 2018 Jan;147:211-220. doi: 10.1016/j.bcp.2017.10.006. Epub 2017 Oct 20. Review. PubMed PMID: 29061342. 2. Cokorinos EC, Delmore J, Reyes AR, Albuquerque B, Kjøbsted R, Jørgensen NO, Tran JL, Jatkar A, Cialdea K, Esquejo RM, Meissen J, Calabrese MF, Cordes J, Moccia R, Tess D, Salatto CT, Coskran TM, Opsahl AC, Flynn D, Blatnik M, Li W, Kindt E, Foretz M, Viollet B, Ward J, Kurumbail RG, Kalgutkar AS, Wojtaszewski JFP, Cameron KO, Miller RA. Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice. Cell Metab. 2017 May 2;25(5):1147-1159.e10. doi: 10.1016/j.cmet.2017.04.010. PubMed PMID: 28467931.