| Description | PF-670462 is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations. |
| Target activity | CK1ε:7.7 ± 2.2 nM |
| Synonyms | PF670462 |
| molecular weight | 410.32 |
| Molecular formula | C19H22Cl2FN5 |
| CAS | 950912-80-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/mL (134.04 mM) |
| References | 1. Daniel I Perez, et al. Med Res Rev.2011,31(6): 924-954. |
| Citations | 1. Huang Q, Jiang M, Xia Z Y, et al. Role of CK1ε-regulated PERIOD2 in STZ-induced diabetic myocardial injury. Frontiers in Bioscience-Landmark. 2022, 27(2): 58-58. |