| Description | PF-4136309 (INCB8761) is a specific, effective, and orally bioavailable CCR2 antagonist. |
| Target activity | CCR2 (rat):13 nM, CCR2 (mouse):17 nM, CCR2 (human):5.2 nM |
| Synonyms | INCB8761, PF 4136309 |
| molecular weight | 568.59 |
| Molecular formula | C29H31F3N6O3 |
| CAS | 1341224-83-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/mL (96.73 mM) |
| References | 1. Discovery of INCB8761/PF-4136309, a Potent, Selective, and Orally Bioavailable CCR2 Antagonist By Xue, Chu-Biao; Wang, Anlai; Han, Qi; Zhang, Yingxin; Cao, Ganfeng; Feng, Hao; Huang, Taisheng; Zheng, Changsheng; Xia, Michael; Zhang, Ke; et ACS Med. Chem. Lett., 2011, 2 (12), pp 913-918 |