| Description | PF-07284892 (ARRY-558) is an orally active, potent inhibitor of SHP2, demonstrating an IC50 of 21 nM, and is known to reduce the expression of pERK [1] [2]. |
| In vitro | PF-07284892（100 nM；4, 18小时）与lorlatinib（0-450 nM）、binimetinib（0-160 nM）协同作用，在H3122 lorR-06、VACO-432细胞系中显著抑制pERK表达[2]。 |
| In vivo | PF-07284892（剂量10 mg/kg；口服）展现了优秀的口服生物利用度，在小鼠、大鼠、犬和猴的生物利用度（F%）分别达到85%、94%、102%和64% [2]。 |
| Synonyms | ARRY-558 |
| molecular weight | 439.96 |
| Molecular formula | C21H22ClN7S |
| CAS | 2498597-94-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |