| Description | PET-16 is a HSP70 inhibitor. |
| Synonyms | PET16, PET 16 |
| molecular weight | 443.32 |
| Molecular formula | C26H20BrP |
| CAS | 34387-64-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Bailey CK, Budina-Kolomets A, Murphy ME, Nefedova Y. Efficacy of the HSP70 inhibitor PET-16 in multiple myeloma. Cancer Biol Ther. 2015;16(9):1422-6. doi: 10.1080/15384047.2015.1071743. Epub 2015 Jul 15. PubMed PMID: 26176532; PubMed Central PMCID: PMC4622955. 2. Stetz G, Verkhivker GM. Probing Allosteric Inhibition Mechanisms of the Hsp70 Chaperone Proteins Using Molecular Dynamics Simulations and Analysis of the Residue Interaction Networks. J Chem Inf Model. 2016 Aug 22;56(8):1490-517. doi: 10.1021/acs.jcim.5b00755. Epub 2016 Aug 1. PubMed PMID: 27447295. 3. Budina-Kolomets A, Webster MR, Leu JI, Jennis M, Krepler C, Guerrini A, Kossenkov AV, Xu W, Karakousis G, Schuchter L, Amaravadi RK, Wu H, Yin X, Liu Q, Lu Y, Mills GB, Xu X, George DL, Weeraratna AT, Murphy ME. HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors. Cancer Res. 2016 May 1;76(9):2720-30. doi: 10.1158/0008-5472.CAN-15-2137. Epub 2016 Mar 16. PubMed PMID: 26984758; PubMed Central PMCID: PMC4939897. |