| Description | Pepinemab(VX 15/2503) is a humanized IgG4 monoclonal antibody targeting sematone 4D. Pepinemab has anti-cancer activity and blocks the activity of SEMA4D, which is used to study degenerative diseases similar to Alzheimer's disease. |
| Synonyms | VX 15/2503 |
| molecular weight | N/A |
| CAS | 2097151-87-4 |
| Storage | store at low temperature | store at -80°C |
| References | 1. Shafique MR, et al. A Phase Ib/II Study of Pepinemab in Combination with Avelumab in Advanced Non-Small Cell Lung Cancer. Clin Cancer Res. 2021 Jul 1;27(13):3630-3640. 2. Feigin A, et al. Pepinemab antibody blockade of SEMA4D in early Huntington's disease: a randomized, placebo-controlled, phase 2 trial. Nat Med. 2022 Oct;28(10):2183-2193. |