| Description | Pentamidine is an antifungal and antiprotozoal agent, interacting directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor groove of DNA, thereby interfering with DNA replication. |
| In vitro | Pentamidine 在治疗冈比亚锥虫病血淋巴期、对锑药物耐药的利什曼病和卡氏肺囊虫肺炎方面有效[1]。 |
| Target activity | Leishmania infantum:2.5 μM (IC50) |
| molecular weight | 340.42 |
| Molecular formula | C19H24N4O2 |
| CAS | 100-33-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: Slightly soluble |
| References | 1. Michael S , Kron M A , Brown R B . Pentamidine: A Review[J]. Reviews of Infectious Diseases(5):625. 2. Carton F , Chevalier Y , Nicoletti L , et al. Rationally designed hyaluronic acid-based nano-complexes for pentamidine delivery[J]. International Journal of Pharmaceutics, 2019, 568:118526. |