| Description | Pentabromopseudilin (PBrP), a marine antibiotic derived from Pseudomonas bromoutilis and Alteromonas luteoviolaceus, demonstrates antimicrobial, antitumor, and phytotoxic properties. It acts as a reversible, allosteric inhibitor of myosin Va (MyoVa) and robustly inhibits transforming growth factor-β (TGF-β) activity. PBrP is utilized in researching fibrotic diseases and cancer [1]. |
| In vitro | Pentabromopseudilin（PBrP）（0.01-1 μM，6小时）可抑制TGF-β诱导的Smad蛋白磷酸化及其核内转移[1]。在0.5 μM浓度，6小时处理期内，PBrP同样能够阻断TGF-β激活的转录反应[1]。PBrP在0-1 μM范围内，经过6小时处理，能够抑制A549细胞中TGF-β触发的上皮细胞-间充质转化（EMT）[1]。此外，0.2 μM PBrP在20小时的作用下，能够抑制TGF-β诱发的细胞迁移[1]。PBrP在0.01-1 μM浓度并经过6小时作用，还可增强TβRII降解，从而中断TGF-β信号传递[1]。最后，0.5μM PBrP在0、1、3小时的作用下，能够通过增强细胞膜穴样内陷来促进TβRII的分解，进一步阻止TGF-β的信号传导[1]。 |
| molecular weight | 553.66 |
| Molecular formula | C10H4Br5NO |
| CAS | 10245-81-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |