| Description | PEG4-bis(phosphonic acid diethyl ester) is a polyethylene glycol (PEG) derivative serving as a linker for PROTAC synthesis. It is specifically designed for the creation of proteolysis-targeting chimeras (PROTACs)[1]. |
| In vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| molecular weight | 466.4 |
| Molecular formula | C16H36O11P2 |
| CAS | 106338-06-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
PEG4-bis(phosphonic acid diethyl ester)
CAS No.: 106338-06-1
PEG4-bis(phosphonic acid diethyl ester) is a polyethylene glycol (PEG) derivative serving as a linker for PROTAC synthes
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