| Description | PDS-0330 is a claudin-1 small molecule inhibitor inhibitor.PDS-0330 inhibits claudin-1-dependent CRC progression and binds directly and specifically to claudin-1 with micromolar affinity.PDS-0330 exhibits well characterized pharmacokinetic properties with antitumor and Chemosensitizing activity.PDS-0330 interferes with claudin-1 / Src association to inhibit CRC progression and metastasis. |
| molecular weight | 423.49 |
| Molecular formula | C25H17N3O2S |
| CAS | 2904682-19-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: < 1 mg/mL (insoluble） |
| References | 1. Fatima I, et al. Identification and characterization of a first-generation inhibitor of claudin-1 in colon cancer progression and metastasis. Biomed Pharmacother. 2023;159:114255. |