| Description | PDE4-IN-10 (compound 7a) is a potent inhibitor of PDE4, with an IC 50 of 7.01 μM for PDE4B. PDE4-IN-10 exhibits selectivity, microsomal stability, inhibition of TNF-α and no major toxicities in vitro [1]. |
| In vitro | PDE4-IN-10 (compound 7a) exhibits 64.56% inhibition at 10 μM against PDE4B, 54% inhibition at 30 μM but 17% inhibition at 10 μM against PDE4D which indicates its selectivity (~3.8 fold) towards PDE4B over PDE4D [1]. |
| molecular weight | 243.3 |
| Molecular formula | C18H13N |
| CAS | 2413564-66-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |