| Description | PD 130883 is a potent lipophilic quinazoline antifolate. |
| Synonyms | PD-130883, PD130883 |
| molecular weight | 349.34 |
| Molecular formula | C18H15N5O3 |
| CAS | 123685-36-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Seither RL, Trent DF, Mikulecky DC, Rape TJ, Goldman ID. Effect of direct suppression of thymidylate synthase at the 5,10-methylenetetrahydrofolate binding site on the interconversion of tetrahydrofolate cofactors to dihydrofolate by antifolates. Influence of degree of dihydrofolate reductase inhibition. J Biol Chem. 1991 Mar 5;266(7):4112-8. PubMed PMID: 1825652. |