| Description | PD 117588 is a quinolone against bacterial isolates from cancer patients. PD 117558 has a broad antimicrobial spectrum with excellent activity against all Gram-positive isolates (including methicillin-resistant Staphylococcus aureus, coagulase-negative staphylococci, Streptococcus faecalis and Group JK-corynebacteria). PD 117588 is also extremely active against Gram-negative bacilli with the exception of Pseudomonas aeruginosa against which ciprofloxacin was more active. PD 117588 has lower minimal inhibitory concentrations for most organisms tested than either imipenem or ceftazidime. |
| Synonyms | PD117588, PD-117588 |
| molecular weight | 391.41 |
| Molecular formula | C20H23F2N3O3 |
| CAS | 99734-97-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Rolston KV, LeBlanc B, Gooch G, Ho DH, Bodey GP. In-vitro activity of PD 117558, a new quinolone against bacterial isolates from cancer patients. J Antimicrob Chemother. 1989 Mar;23(3):363-71. PubMed PMID: 2732120. |