| Description | PB118 has the capacity to effectively clear Aβ deposits by augmenting phagocytosis, enhance the tubulin/microtubule network through increased acetyl α-tubulin levels, modulate various inflammation-associated cytokines and chemokines, and notably diminish phospho-tau (p-tau) levels linked to Alzheimer's disease (AD). The IC50 of PB118 for HDAC6 is 5.6 nM. |
| molecular weight | 314.35 |
| Molecular formula | C18H19FN2O2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Mondal P, Bai P, Gomm A, et al. Structure-Based Discovery of A Small Molecule Inhibitor of Histone Deacetylase 6 (HDAC6) that Significantly Reduces Alzheimer's Disease Neuropathology. Adv Sci (Weinh). Published online November 21, 2023. 2. Bai P, Mondal P, Bagdasarian FA, et al. Development of a potential PET probe for HDAC6 imaging in Alzheimer's disease. Acta Pharm Sin B. 2022;12(10):3891-3904. |