| Description | Pavinetant (MLE-4901) is an orally available neurokinin-3 receptor (NK3R) antagonist used to improve menopausal symptoms. |
| In vitro | Pavinetant（AZD2624）是一种有效的 NK3 受体拮抗剂，对微粒体 CYP3A4/5 活性具有良好的抑制作用[1]。 |
| Synonyms | MLE-4901, AZD4901, AZD2624 |
| molecular weight | 459.56 |
| Molecular formula | C26H25N3O3S |
| CAS | 941690-55-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 80 mg/mL (87.04 mM), Sonication is recommended. |
| References | 1. Li Y, et al. In vitro assessment of metabolic drug–drug interaction potential of AZD2624, neurokinin-3 receptor antagonist, through cytochrome P(450) enzyme identification, inhibition, and induction studies. Xenobiotica. 2010 Nov;40(11):721-9. |