| Description | PAT-347 is a potent inhibitor of Autotaxin (ATX), a secreted enzyme responsible for the hydrolysis of lysophosphatidylcholine (LPC) to the bioactive lysophosphatidic acid (LPA) and choline. |
| Synonyms | PAT-347, PAT347, PAT 347 |
| molecular weight | 560.98 |
| Molecular formula | C28H20ClF2N2NaO3S |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Structure–Activity Relationships of Small Molecule Autotaxin Inhibitors with a Discrete Binding Mode Lisa M. MillerWillem-Jan KeuneDiana CastagnaLouise C. YoungEmma L. DuffyFrances PotjewydFernando Salgado-PoloPaloma Engel GarcíaDima SemaanJohn M. PritchardAnastassis PerrakisSimon J. F. MacdonaldCraig JamiesonAllan J. B. Watson Publication Date (Web): December 16, 2016 (Article) doi: 10.1021/acs.jmedchem.6b01597 |