| Description | PARP1-IN-8 (N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide) is an effective inhibito of PARP1 (IC50 = 97 nM). |
| In vitro | PARP1-IN-8 (0, 0.1, 1, 10 μM; 24, 48 h) showed significantly potent anti-proliferative activity against A549 cells and didn’t display any significant cytotoxicity on HFF cells[1]. |
| Target activity | PARP1:97 nM |
| Synonyms | N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide |
| molecular weight | 403.86 |
| Molecular formula | C23H18ClN3O2 |
| CAS | 836640-15-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 1 mg/ml, Sonication is recommended. |
| References | 1. Almahli H, Hadchity E, Jaballah MY, Daher R, Ghabbour HA, Kabil MM, Al-Shakliah NS, Eldehna WM. Development of novel synthesized phthalazinone-based PARP-1 inhibitors with apoptosis inducing mechanism in lung cancer. Bioorg Chem. 2018 Apr;77:443-456. |