| Description | Pamiparib, also known as BGB-290, is a highly potent and selective PARP inhibitor with favorable drug metabolism and pharmacokinetic properties. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of single-strand DNA breaks via the base-excision repair (BER) pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability, and eventually leads to apoptosis. BGB-290 may both potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo- and radioresistance. |
| molecular weight | 352.36 |
| Molecular formula | C16H21FN4O4 |
| CAS | 1858211-28-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |