| Description | Palbociclib D8 is a deuterium labeled Palbociclib. Palbociclib is a selective and orally active inhibitor of CDK4 and CDK6 (IC50s of 11 and 16 nM, respectively). |
| Target activity | MAPK:8000 nM, DYRK1A:2000 nM, CDK4-CyclinD3:9 nM, CDK4-CyclinD1:11 nM, CDK6-CyclinD2:16 nM |
| Synonyms | PD 0332991 D8, Palbociclib D8 |
| molecular weight | 455.58 |
| Molecular formula | C24H29N7O2 |
| CAS | 1628752-83-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Fry DW, et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther. 2004 Nov;3(11):1427-38. |