| Description | Paeonoside, found in P. suffruticosa, is biologically active and can promote wound healing and migration during osteoblast differentiation. Paeonoside has certain antidiabetic activity and may prevent sepsis and death from sepsis. Paeonoside has no cytotoxic effect on preosteoblasts of MC3T3-E1 cells, significantly restores the wound area and promotes cell migration and alkaline phosphatase (ALP) staining and its activity in a dose-dependent manner. |
| In vitro | Paeonoside（0.1-100μM，24小时）对MC3T3-E1前成骨细胞没有表现出细胞毒性，即使在0.1至100μM浓度范围内处理24小时也是如此。[1] 当利用含骨生成补充剂（OS）培养基诱导MC3T3-E1前成骨细胞分化时，PASI（1-30μM，24小时）的处理显著促进了伤口区域的修复和细胞迁移，并且这种作用具有剂量依赖性。此外，PASI还以剂量依赖的方式促进了碱性磷酸酶（ALP）的染色和活性。[1] |
| molecular weight | 328.31 |
| Molecular formula | C15H20O8 |
| CAS | 20309-70-0 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 22.5 mg/mL (68.53 mM) |
| References | 1. Park KR, et al. Biological Mechanisms of Paeonoside in the Differentiation of Pre-Osteoblasts and the Formation of Mineralized Nodules. Int J Mol Sci. 2021;22(13):6899. 2. Li G, et al. Protective constituents against sepsis in mice from the root cortex of Paeonia suffruticosa. Arch Pharm Res. 2004;27(11):1123-1126. |