| Description | PACMA 31 is an irreversible and covalent inhibitor of protein disulfide isomerase (PDI) with an IC50 of 10 μM. PACMA 31 significantly suppresses ovarian tumor growth and exhibits tumor targeting ability. |
| In vitro | 在OVCAR-8细胞中，PACMA 31（0-10 μM）通过剂量依赖的方式强效抑制集落形成[1]。 |
| In vivo | 在人类卵巢癌小鼠异种移植模型中，PACMA 31（20-200 mg/kg）通过腹腔注射或口服给药，在第62天分别显著抑制肿瘤生长85%和65%[1]。 |
| molecular weight | 430.47 |
| Molecular formula | C21H22N2O6S |
| CAS | 1401089-31-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 95 mg/mL (220.69 mM), Sonication is recommended. |
| References | 1. Xu S, et al. Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment. Proc Natl Acad Sci U S A. 2012;109(40):16348-16353. |