| Description | PAβN dihydrochloride (MC-207,110 dihydrochloride) is an inhibitor of efflux pump. |
| In vitro | PAβN有效降低了九株耐氟哌酸(ciprofloxacin)菌株的最低抑菌浓度(MICs)，其中四株的敏感性提高了两倍。此外，PAβN也恢复了五株耐氟哌酸菌株对该化合物的敏感性。同时，二十株耐氟哌酸菌株对NMP的反应明显，表现为氟哌酸MICs明显改善[2]。 |
| Synonyms | MC-207,110 dihydrochloride, Phe-Arg-β-naphthylamide dihydrochloride |
| molecular weight | 519.47 |
| Molecular formula | C25H32Cl2N6O2 |
| CAS | 100929-99-5 |
| Storage | store at low temperature,keep away from moisture|Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 14.29 mg/mL (27.51 mM), Sonication is recommended. DMSO: 95 mg/mL (182.88 Mm) |
| References | 1. Lomovskaya O, et al. Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy. Antimicrob Agents Chemother. 2001 Jan;45(1):105-16. 2. Kurinčič M, et al. Effects of efflux pump inhibitors on erythromycin, ciprofloxacin, and tetracycline resistance in Campylobacter spp. isolates. Microb Drug Resist. 2012 Oct;18(5):492-501. 3. Lamers RP, et al. The efflux inhibitor phenylalanine-arginine beta-naphthylamide (PAβN) permeabilizes the outer membrane of gram-negative bacteria. PLoS One. 2013;8(3):e60666. |
| Citations | 1. Liu C, Wang L, Wang P, et al.The Mechanism of Tigecycline Resistance in Acinetobacter baumannii Revealed by Proteomic and Genomic Analysis.International Journal of Molecular Sciences.2023, 24(10): 8652. |