| Description | p-SCN-Bn-DOTA is a chelator that chelates both radionuclides and conjugated monoclonal antibodies, which can be used as a tracer for radiation-guided surgery and can be used for radioimmunoassay studies of tumors. |
| In vitro | p-SCN-Bn-DOTA与五种不同的金属离子形成络合物，这些金属离子包括Lu(III)、Gd(III)、In(III)、Y(III)和Cu(II)。[2] |
| molecular weight | 551.61 |
| Molecular formula | C24H33N5O8S |
| CAS | 127985-74-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: < 1 mg/mL (insoluble） |
| References | 1. Vera DRB, et, al. Preclinical evaluation of (177)lu-nimotuzumab: a potential tool for radioimmunotherapy of epidermal growth factor receptor-overexpressing tumors. Cancer Biother Radiopharm. 2011 Jun;26(3):287-97. 2. Giannini G, et, al. Synthesis and preliminary in vitro evaluation of DOTA-Tenatumomab conjugates for theranostic applications in tenascin expressing tumors. Bioorg Med Chem. 2019 Aug 1;27(15):3248-3253. |