| Description | p-cumylphenol can treat R enal Tubular Cyst Formation in Newborn Rats. |
| In vivo | P-cumylphenol 在新生大鼠引发了外髓收集管中发展的多个肾囊肿，且暗示上皮细胞增殖可能在囊性病变的诱导中扮演了某些角色。 |
| Animal experiments | Fifteen animals per sex were treated orally with 300 mg/kg/day of p-cumylphenol for up to 18 days from postnatal day (PND) 4 and were sacrificed on PNDs 8, 12, 19 and 22 and after a 7 day recovery period. On PNDs 8 and 12, slight dilatation of the collecting ducts was frequently observed in the medulla and slight papillary necrosis was also noted in some cases. These dilated collecting ducts were lined with slightly hyperplastic epithelial cells. On PNDs 19 and 22, multiple large cystic changes arising from the collecting ducts in the outer medulla were seen. |
| molecular weight | 212.29 |
| Molecular formula | C15H16O |
| CAS | 599-64-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 22.5 mg/mL (105.99 mM) |
| References | 1. Nakazawa T , Kasahara K , Ikezaki S , et al. Renal Tubular Cyst Formation in Newborn Rats Treated with p-Cumylphenol[J]. Journal of Toxicologic Pathology, 2009, 22(2):125-131. |