| Description | p-Cresyl Sulfate is a major uremic toxin found in the blood of patients with chronic kidney disease (CKD), derived from the metabolites of tyrosine and phenylalanine in the liver. |
| In vitro | 将NRK-52细胞系用尿毒症毒素(p-Cresyl Sulfate和Indoxyl sulfate)处理。数据显示，在24-96小时内，以100μM Indoxyl sulfate（IS）处理的NRK-52细胞的存活率超过90%，而以100μM p-Cresyl Sulfate（PCS）处理的NRK-52细胞的存活率大约为80-90%。结果表明，与IS相比，PCS对大鼠肾小管上皮细胞具有更强的细胞毒性作用[2]。 |
| molecular weight | 188.2 |
| Molecular formula | C7H8O4S |
| CAS | 3233-58-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/ml (292.24 mM) |
| References | 1. Gryp T, et al. p-Cresyl Sulfate. Toxins (Basel). 2017 Jan 29;9(2):52. 2. Wei CW,et al . Curcumin enhances p-cresyl sulfate-induced cytotoxic effects on renal tubular cells. Int J Med Sci. 2022 Jun 27;19(7):1138-1146. |