| Description | Oxyphenisatine (Oxyphenisatin), along with related bisacodyl, sodium picosulfate, and phenolphthalein, isa precursor of oxyphenisatine, which has anticancer activity. Oxyphenisatine is often used as a laxative and can cause liver damage when used long-term. |
| In vitro | Oxyphenisatin展现出抗增殖性能。Oxyphenisatin acetate (OXY, NSC 59687) 作为oxyphenisatin的前药。OXY能够抑制乳腺癌细胞系MCF7, T47D, HS578T, 和MDA-MB-468的生长（IC 50 =0.8, 0.6, 2.1, 1.8 μM）。这一作用与特定的翻译抑制有关，伴随着营养感应的真核翻译启动因子2α (eIF2α) 激酶，GCN2和PERK的迅速磷酸化。 |
| In vivo | 毒性研究表明，小鼠对每日一次以IP方式给予OXY 300 mg/kg或每日两次200 mg/kg显示出耐受性。连续10天，每日一次通过IP途径给予OXY 300 mg/kg，从第33天到第52天，观察到显著较小的肿瘤体积。[1] |
| Synonyms | Oxyphenisatin |
| molecular weight | 317.34 |
| Molecular formula | C20H15NO3 |
| CAS | 125-13-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 90.0 mg/mL (283.6 mM) |
| References | 1. Morrison BL, et al. Oxyphenisatin acetate (NSC 59687) triggers a cell starvation response leading to autophagy, mitochondrial dysfunction, and autocrine TNFα-mediated apoptosis. Cancer Med. 2013;2(5):687-700. 2. National Center for Biotechnology Information (2023). A method of treating triple-negative breast cancer. US-2021220329-A1. |