| Description | Oxybutynin (Ditropan) is a synthetic anticholinergic agent that is used for treatment of urinary incontinence and overactive bladder syndrome. |
| In vitro | 在大鼠大脑皮质和纹状体中,Oxybutynin以剂量依赖的方式显着降低结合电位（BP）. |
| In vivo | 在人肝微粒体中,Oxybutynin抑制CYP3A4-和CYP2D6-相关活性（分别为睾酮6β-羟化酶和右美沙芬O-脱甲基酶）。Oxybutynin（30,100 nM）竞争性拮抗乙酰胆碱诱导的收缩。 |
| Synonyms | Oxytrol, 奥昔布宁, Ditropan, Oxibutyninum |
| molecular weight | 357.49 |
| Molecular formula | C22H31NO3 |
| CAS | 5633-20-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: 66 mg/mL (184.6 mM) DMSO: 45 mg/mL (125.88 mM), Sonication is recommended. |
| References | 1. Lukkari E, et al. Pharmacol Toxicol, 1998, 82(4), 161-166. 2. Tonini M, et al. J Pharm Pharmacol, 1987, 39(2), 103-107. 3. Comar JF, et al. Pharmacol Toxicol, 2003, 93(3), 147-152. 4. Yoshida A, et al. Life Sci, 2010, 87(5-6), 175-180. 5. Guarneri L, et al. Pharmacol Res, 1991, 24(3), 263-272. |