| Description | Oxaprotiline is an antidepressant compound. It is a norepinephrine reuptake inhibitor that blocks histamine H1 receptors. Oxaprotiline has been studied for its efficacy in treating hospitalized patients with depression, but it is not on the market. |
| Synonyms | Oxaprotilinum |
| molecular weight | 293.4 |
| Molecular formula | C20H23NO |
| CAS | 56433-44-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Birthelmer A, Ehret A, Riegert C, Rothmaier AK, Leemhuis J, Jackisch R. Modulation of electrically evoked serotonin release in cultured rat raphe neurons. J Neurochem. 2007 Mar;100(6):1613-25. PubMed PMID: 17348865. 2. Ding YS, Lin KS, Logan J. PET imaging of norepinephrine transporters. Curr Pharm Des. 2006;12(30):3831-45. Review. PubMed PMID: 17073682. 3. Löffler M, Bubl B, Huethe F, Hubbe U, McIntosh JM, Jackisch R, Feuerstein TJ. Dopamine release in human neocortical slices: characterization of inhibitory autoreceptors and of nicotinic acetylcholine receptor-evoked release. Brain Res Bull. 2006 Jan 30;68(5):361-73. Epub 2005 Oct 17. PubMed PMID: 16377444. 4. Ding YS, Lin KS, Logan J, Benveniste H, Carter P. Comparative evaluation of positron emission tomography radiotracers for imaging the norepinephrine transporter: (S,S) and (R,R) enantiomers of reboxetine analogs ([11C]methylreboxetine, 3-Cl-[11C]methylreboxetine and [18F]fluororeboxetine), (R)-[11C]nisoxetine, [11C]oxaprotiline and [11C]lortalamine. J Neurochem. 2005 Jul;94(2):337-51. PubMed PMID: 15998285. |