| Description | Oxacillin is an orally active synthetic penicillin. Oxacillin shows good bactericidal activity against staphylococci and other gram-positive pathogens. |
| In vitro | Oxacillin inhibits gram positive pathogens with MICs of 0.05, 0.09, 0.32 and 0.80 μg/mL against group A streptococci, Pneutnococci, susceptible staphylococci and penicillin-resistant staphylococci, respectively [1]. The Oxacillin-resistant strains are highly resistant to other penicillins [1]. |
| In vivo | Oxacillin (50-800 mg/kg; s.c.; once) shows curative dose (CD 50 ) of 253.3 mg/kg in mice infected with Staphylococcus aureus Evans. The oral CD 50 of Oxacillin is 187.2 mg/kg [2]. Animal Model: CD-1 strain male albino mice infected with S. aureus Evans [2] Dosage: 50, 100, 200, 400 and 800 mg/kg Administration: Subcutaneous injection, once Result: Showed therapeutic activity with CD 50 of 253.3 mg/kg. |
| molecular weight | 401.44 |
| Molecular formula | C19H19N3O5S |
| CAS | 66-79-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |