| Description | Oxaceprol (N-Acetyl-L-hydroxyproline) is an established therapeutic agent for osteoarthritis. |
| In vivo | Oxaceprol，一种用于治疗骨关节炎的化合物，在体外对巨噬细胞前列腺素E2的释放无影响，并且在高剂量（18-150 mg/kg p.o.）下能抑制卡拉胶爪肿胀。在同一剂量范围内，Oxaceprol与吲哚美辛（3 mg/kg p.o.）具有相当的抑制作用，对酵母过敏性和在6-50 mg/kg/天 p.o.剂量下对棉球肉芽肿形成有轻微、不稳定的抑制效果[1]。 |
| Synonyms | 奥沙西罗, N-Acetyl-L-hydroxyproline, N-乙酰-L-4-羟基脯氨酸 |
| molecular weight | 173.17 |
| Molecular formula | C7H11NO4 |
| CAS | 33996-33-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 100 mg/mL (577.47 mM) |
| References | 1. Ionac M , Parnham M J , Plauchithiu M , et al. OXACEPROL, AN ATYPICAL INHIBITOR OF INFLAMMATION AND JOINT DAMAGE[J]. pharmacological research, 1996, 33(6):367-373. 2. Herrmann G , Steeger D , Klasser M , et al. Oxaceprol is a Well-Tolerated Therapy for Osteoarthritis with Efficacy Equivalent to Diclofenac[J]. Clinical Rheumatology, 2000, 19(2):99-104. |
| Citations | 1. Jiang F, Chen Y, Yu J, et al.Repurposed Fenoprofen Targeting SaeR Attenuates Staphylococcus aureus Virulence in Implant-Associated Infections.ACS Central Science.2023 |