| Description | OSBPL7-IN-1 is an orally active inhibitor of oxysterol binding protein like 7 (OSBPL7). OSBPL7-IN-1 promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression[1]. |
| In vitro | OSBPL7-IN-1在培养的人类肾小球足细胞中增加质膜ATP结合盒转运蛋白（ABCA1），并显著提高ABCA1依赖的胆固醇外排[1]。 |
| In vivo | OSBPL7-IN-1（100mg/kg；口服灌胃；每日一次；连续28天）治疗能够使蛋白尿恢复正常，并防止蛋白尿性肾病小鼠模型中的肾功能下降[1]。 |
| molecular weight | 463.28 |
| Molecular formula | C20H19Cl2F3N2O3 |
| CAS | 1269826-44-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 11 mg/mL (23.74 mM), Sonication is recommended. |