| Description | Ornidazole (Tiberal) is a nitroimidazole antiprotozoal agent used in ameba and trichomonas infections. It is partially plasma-bound and also has radiation-sensitizing action. |
| In vitro | Ornidazole是一种5-硝基咪唑衍生物，对原虫和厌氧细菌具有活性。它被转化为还原产物，这些产物与DNA相互作用，破坏螺旋状DNA结构和链条，导致易感生物中的蛋白质合成抑制和细胞死亡。 |
| Synonyms | Tiberal, Ornidazolum, NSC 95075, Ro 7-0207, 奥硝唑 |
| molecular weight | 219.63 |
| Molecular formula | C7H10ClN3O3 |
| CAS | 16773-42-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | H2O: 2 mg/mL (9.1 mM) Ethanol: 41 mg/mL (186.7 mM) DMSO: 55 mg/mL (250.42 mM), Sonication is recommended. |
| References | 1. Rutgeerts P et al. Gastroenterology, 2005, 128(4):856-861. 2. Goldstein EJ et al. Antimicrob Agents Chemother, 1978, 14(4), 609-613. |
| Citations | 1. Lai S, Kumari A, Liu J, et al. Chemical screening reveals Ronidazole is a superior prodrug to Metronidazole for nitroreductase-induced cell ablation system in zebrafish larvae. Journal of Genetics and Genomics. 2021 |