| Description | OptoBI-1 is a light-sensitive molecule that is photochromic TRPC3 agonist. OptoBI-1 asts as a photopharmacological tool to control of neuronal firing [1]. |
| In vitro | OptoBI-1 enables high-precision, temporal control of TRPC3-linked cell functions like neuronal firing and endothelial Ca 2+ transients [1]. |
| molecular weight | 523.67 |
| Molecular formula | C32H37N5O2 |
| CAS | 2415272-11-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: Soluble |
| References | 1. Tiapko et al (2019) Lipid-independent control of endothelial and neuronal TRPC3 channels by light. Chem.Sci. 10 2837 2. Curcic et al (2019) Photopharmacology and opto-chemogenetics of TRPC channels-some therapeutic visions. Pharmacol.Ther. 200 13 PMID:30974125 3. Curcic et al (2019) TRPC-mediated Ca2+ signaling and control of cellular functions. Semin.Cell Dev.Biol. 94 28 PMID:30738858 4. Lichtenegger et al (2018) An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel. Nat.Chem.Biol. 14 396 PMID:29556099 |