| Description | ONO-AE3-208 (AE 3-208) is an EP4 antagonist. It suppresses cell migration, invasion, and metastasis of prostate cancer. |
| In vitro | ONO-AE3-208在存在EET合成抑制剂MS-PPOH的条件下，能消除CTGF。花生四烯酸引起附着的Af-Art的剂量依赖性扩张，而这种效果被ONO-AE3-208阻断[2]。 |
| In vivo | 在小鼠中，ONO-AE3-208 有效抑制了 PC3 细胞体内骨转移[1]。与 ONO-AE3-208 处理组相比，对照组的光子肿瘤负担随时间明显增加。前者的转移形成率显著高于后者。ONO-AE3-208 处理动物的转移形成中位时间为 29 天，而对照组为 21 天[3]。 |
| Target activity | EP3 receptor:30 nM (Ki), FP:790 nM (Ki), TXR:2400 nM (Ki), EP4:1.3 nM (Ki) |
| Synonyms | AE 3-208 |
| molecular weight | 404.43 |
| Molecular formula | C24H21FN2O3 |
| CAS | 402473-54-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: Insoluble DMSO: 70 mg/mL (173.08 mM), Sonication is recommended. |
| References | 1. Xu S, et al. An EP4 Antagonist ONO-AE3-208 Suppresses Cell Invasion, Migration, and Metastasis of Prostate Cancer. Cell Biochem Biophys. 2014 Apr 18. 2. Ren Y, et al. Prostaglandin E2 mediates connecting tubule glomerular feedback. Hypertension. 2013 Dec;62(6):1123-8. 3. Xu S, et al. Inhibitory effect of ONO-AE3-208 on the formation of bone metastasis of prostate cancer in mice. Zhonghua Nan Ke Xue. 2014 Aug;20(8):684-9. |