| Description | ONO-8130 is an orally available antagonist of EP1 receptor. |
| In vivo | Oral preadministration of ONO-8130 at 0.3-30 mg/kg strongly prevented both the bladder pain-like behavior and referred hyperalgesia in a dose-dependent manner, but had slight effect on the increased bladder weight and vascular permeability.?Oral ONO-8130 at 30 mg/kg also reversed the established cystitis-related bladder pain.?Intravesical administration of prostaglandin E2 caused prompt phosphorylation of ERK in the L6 spinal cord, an effect blocked by ONO-8130.?The prostaglandin E2/EP1 system participates in processing of cystitis-related bladder pain, and that EP1 antagonists including ONO-8130 are useful for treatment of bladder pain, particularly in interstitial cystitis.?Prostaglandin E2 contributes to cystitis-related bladder pain via EP1 receptors in mice, indicating possible therapeutic usefulness of selective EP1 antagonists[1]. |
| molecular weight | 500.63 |
| Molecular formula | C25H28N2O5S2 |
| CAS | 459841-96-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 5 mg/mL (10 mM) |
| References | 1. Miki T , Matsunami M , Nakamura S , et al. ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis.[J]. Pain, 2011, 152(6):1373-1381. 2. Baker S , Kraak G . Investigating the role of prostaglandin receptor isoform EP4b in zebrafish ovulation[J]. General and Comparative Endocrinology, 2019, 283:113228. |