| Description | OICR-9429-N-C2-NH2, a ligand for WDR5, intermediate 2, serves as a crucial compound in the synthesis of PROTACs. |
| In vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
| Synonyms | OICR-9429-N-C2-NH2 |
| molecular weight | 597.687 |
| Molecular formula | C31H38F3N7O2 |
| CAS | 2407457-55-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Jin J, et, al. Wd40 repeat domain protein 5 (wdr5) degradation / disruption compounds and methods of use. WO2019246570A1. 2. Chung CW, et, al. Structural Insights into PROTAC-Mediated Degradation of Bcl-xL. ACS Chem Biol. 2020 Sep 18;15(9):2316-2323. |