| Description | Odelepran (LY2196044) is an opioid receptor antagonist under development for the treatment of alcohol dependence. |
| Synonyms | LY-2196044, LY 2196044, LY2196044 |
| molecular weight | 373.42 |
| Molecular formula | C20H24FN3O3 |
| CAS | 676501-25-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Wong CJ, Witcher J, Mallinckrodt C, Dean RA, Anton RF, Chen Y, Fijal BA, Ouyang H, Dharia S, Sundseth SS, Schuh KJ, Kinon BJ. A phase 2, placebo-controlled study of the opioid receptor antagonist LY2196044 for the treatment of alcohol dependence. Alcohol Clin Exp Res. 2014 Feb;38(2):511-20. doi: 10.1111/acer.12257. Epub 2013 Sep 6. PubMed PMID: 24010675. 2. Ding X, He M, Kulkarni R, Patel N, Zhang X. Investigation of clinical pharmacokinetic variability of an opioid antagonist through physiologically based absorption modeling. J Pharm Sci. 2013 Aug;102(8):2859-74. doi: 10.1002/jps.23629. Epub 2013 Jun 11. PubMed PMID: 23761048. 3. Hillemacher T, Heberlein A, Muschler MA, Bleich S, Frieling H. Opioid modulators for alcohol dependence. Expert Opin Investig Drugs. 2011 Aug;20(8):1073-86. doi: 10.1517/13543784.2011.592139. Epub 2011 Jun 9. Review. PubMed PMID: 21651459. |