| Description | Odanacatib is an inhibitor of cathepsin K with potential anti-osteoporotic activity. |
| In vitro | 在大鼠中,Odanacatib（10 mg/kg）具有良好清除能力(Cl: 2 mL kg-1 min-1), 低量分布 (Vdss: 1.1 L kg-1), 半衰期 (T1/2: 6 小时),及口服生物有效性(F: 8%). |
| In vivo | Odanacatib可以作用于人组织蛋白酶 K(IC50=0.2 nM)和兔组织蛋白酶 K(IC50=1 nM)。在人细胞酶实验中,Odanacatib也可起到作用,IC50为5 nM。 |
| Target activity | Cathepsin K (rabbit):1 nM, Cathepsin K (human):0.2 nM |
| Synonyms | 奥达卡替, 奥当卡替, MK-0822 |
| molecular weight | 525.56 |
| Molecular formula | C25H27F4N3O3S |
| CAS | 603139-19-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: 93 mg/mL (177 mM) |
| References | 1. Gauthier JY, et al. Bioorg Med Chem Lett. 2008, 18(3), 923-928. 2. Leung P, et al. Bone. 2011, 49(4), 623-635. 3. Pennypacker BL, et al. J Bone Miner Res. 2011, 26(2):252-262. 4. Masarachia PJ, et al. J Bone Miner Res. 2012, 27(3), 509-523. |