| Description | Octahydrocurcumin has antioxidant and and anti-inflammatory activities, it can inhibit the lipopolysaccharide (LPS)-induced inflammatory response via the mechanism of inhibiting NF-kB translocation to the nucleus. Octahydrocurcumin exhibits potent cytotoxic effect (IC50 =19.46 ug/mL) and shows high antimicrobial activity. |
| In vitro | OKT3-induced PBMC proliferation was inhibited by curcumin, isocurcumin, bisdesmethoxy-, diacetyl-, tetrahydro-, hexahydro-, and octahydrocurcumin as well as by vanillin, ferulic acid, and dihydroferulic acid with IC50-values of 2.8, 2.8, 6.4, 1.0, 25, 38, 82, 729, 457, and >1,000?μM, respectively. The investigated substances with the strongest effect on radical scavenging were tetrahydro-, hexahydro-, and octahydrocurcumin with IC50?values of 10.0, 11.7, and 12.3?μM, respectively. IC50-values of dihydroferulic acid, ferulic acid, and curcumin were 19.5, 37, and 40?μM. The substances with the lowest radical scavenging activities were vanillin, isocurcumin, diacetylcurcumin, and bisdesmethoxycurcumin with IC50?values higher than 100?μM each[1]. |
| molecular weight | 376.44 |
| Molecular formula | C21H28O6 |
| CAS | 36062-07-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: 10 mg/mL (26.56 mM), Sonication is recommended. DMSO: 100 mg/mL (265.65 mM), Sonication is recommended. |
| References | 1. Different Curcuminoids Inhibit T-Lymphocyte Proliferation Independently of Their Radical Scavenging Activities. Pharmaceutical Research,2008, 25,(8):1822-7. 2. Comparative antioxidant activities of curcumin and its demethoxy and hydrogenated derivatives. Biol.Pharm. Bull., 2007, 30(1):74-8. |