| Description | Ochratoxin A-13C20is intended for use as an internal standard for the quantification of ochratoxin A by GC- or LC-MS. Ochratoxin A is a mycotoxin that has been found inAspergillusandPenicillium.1It increases lipid peroxide levels and the number of apoptotic cells, as well as reduces superoxide dismutase activity in rat kidney when administered at a dose of 120 μg/kg.2Topical application of ochratoxin A (80 μg/mouse) induces DNA damage, cell cycle arrest at the G0/G1phase, and apoptosis in mouse skin cells.1It also initiates tumor formation in a two-stage mouse skin tumorigenesis model. Ochratoxin A has been found as a contaminant in a variety of foods.3 |
| Synonyms | Ochratoxin A-13C20 |
| molecular weight | 423.66 |
| Molecular formula | C20H18ClNO6 |
| CAS | 911392-42-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Acetonitrile: Soluble |
| References | 1. Kumar, R., Ansari, K.M., Chaudhari, B.P., et al.Topical application of ochratoxin A causes DNA damage and tumor initiation in mouse skinPLoS One7(10)(2012) 2. Petrik, J., Zani?-Grubisi?, T., Barisi?, K., et al.Apoptosis and oxidative stress induced by ochratoxin A in rat kidneyArch. Toxicol.77(12)685-693(2003) 3. Program, N.T.Ochratoxin A: CAS No. 303-47-9Report on Carcinogens12335-337(2011) |