| Description | Obtusifoliol is a specific inhibitor of CYP51(Trypanosoma brucei (TB) and human CYP51 with Kd values of 1.2 μM and 1.4 μM, respectively). |
| In vitro | Obtusifoliol inhibit MCF-7 and MDA-MB231 breast cancer cells proliferation via arresting cell cycle progression and induction of apoptosis |
| molecular weight | 426.72 |
| Molecular formula | C30H50O |
| CAS | 16910-32-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Lepesheva GI, et al. CYP51 from Trypanosoma brucei is obtusifoliol-specific.Biochemistry. 2004 Aug 24;43(33):10789-99. 2. Aghaei M, et al Obtusifoliol related steroids from Euphorbia sogdiana with cell growth inhibitory activity and apoptotic effects on breast cancer cells (MCF-7 and MDA-MB231). Steroids. 2016 Nov;115:90-97. doi: 10.1016/j.steroids.2016.07.008. Epub 2016 Jul 26. |