| Description | NVP-CGM097 sulfate is a potent and selective inhibitor of MDM2 (hMDM2, IC50 of 1.7±0.1 nM). |
| In vitro | NVP-CGM097 is able to significantly redistribute wild-type p53 into the cell nucleus with an IC50 of 0.224 μM, demonstrating its ability to inhibit the p53:MDM2 interaction in living cells.?NVP-CGM097 significantly inhibits the proliferation of cells expressing wild-type p53, while sparing the p53 null cells with a 35-58-fold difference.?NVP-CGM097 inhibtis HCT116 (p53WT/WT) with IC50 of 454±136 nM[1]. |
| Target activity | MDM2 (human):1.7±0.1 nM |
| Synonyms | CGM097 sulfate |
| molecular weight | 757.34 |
| Molecular formula | C38H49ClN4O8S |
| CAS | 1313367-56-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | H2O: 140 mg/mL (184.86 mM) |
| References | 1. Holzer P, et al. Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors. J Med Chem. 2015 Aug 27;58(16):6348-58. |