| Description | NVP-AAD777 is a specific VEGFR-2 inhibitor. |
| Synonyms | AAD-777, NVP-AAD-777, NVP AAD 777 |
| molecular weight | 448.36 |
| Molecular formula | C22H14F6N4 |
| CAS | 300842-59-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Edirisinghe I, Yang SR, Yao H, Rajendrasozhan S, Caito S, Adenuga D, Wong C, Rahman A, Phipps RP, Jin ZG, Rahman I. VEGFR-2 inhibition augments cigarette smoke-induced oxidative stress and inflammatory responses leading to endothelial dysfunction. FASEB J. 2008 Jul;22(7):2297-310. doi: 10.1096/fj.07-099481. Epub 2008 Feb 8. PubMed PMID: 18263699; PubMed Central PMCID: PMC4708085. 2. Marwick JA, Stevenson CS, Giddings J, MacNee W, Butler K, Rahman I, Kirkham PA. Cigarette smoke disrupts VEGF165-VEGFR-2 receptor signaling complex in rat lungs and patients with COPD: morphological impact of VEGFR-2 inhibition. Am J Physiol Lung Cell Mol Physiol. 2006 May;290(5):L897-908. Epub 2005 Dec 16. PubMed PMID: 16361360. |