| Description | NUC-7738, a 5′-aryloxy phosphoramidate prodrug of 3′-deoxyadenosine (3′-dA), exhibits potent cytotoxic activity against various hematological cancer cell lines and is utilized in cancer research [1]. |
| In vitro | NUC-7738（化合物7a；0-198 μM；72小时；CCRF-CEM、HL-60、KG-1、MOLT-4、K562、MV4-11、THP-1、HEL92、NCI-H929、RPMI-8226、Jurkat、Z138、RL、HS445、HepG2、MCF-7、Bx-PC-3、HT29、MIA PaCa-2和SW620 细胞）显示出抗肿瘤活性，对白细胞谱系细胞显示出细胞毒作用，其LC50值均小于30 μM [1]。在人肝细胞中，NUC-7738（1 μM）表现出良好稳定性，半衰期为48.1分钟 [1]。此外，与母体核苷相比，NUC-7738在人血浆中的稳定性更高，可维持4小时血浆浓度不变 [1]。 |
| molecular weight | 568.52 |
| Molecular formula | C26H29N6O7P |
| CAS | 2348493-39-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |