| Description | nSMase2-IN-1 is an orally active inhibitor of Neutral sphingomyelinase 2 (nSMase2) with a potent IC50 value of 0.13 ± 0.06 μM. It demonstrates metabolic stability in liver microsomes and possesses a favorable brain-to-plasma ratio, indicating effective oral bioavailability. This compound is utilized in nervous system disease research [1]. |
| In vitro | nSMase2-IN-1（化合物11j）（5μM, 60分钟）在大鼠肝微粒体内显示出优秀的代谢稳定性，经过1小时处理后，剩余率高达95% [1]。 |
| In vivo | nSMase2-IN-1（化合物11j）通过口服给药（10 mg/kg, gavage），在给药后30分钟及2小时的大鼠脑组织样本中显示出有效的脑渗透能力，该研究在雄性Wistar大鼠中进行 [1]。 |
| molecular weight | 247.3 |
| Molecular formula | C12H17N5O |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |